Transatlantic MSC Cruises

MSC Cruises > Transatlantic MSC Cruises

Venture on an incredible cruise holiday, visiting the best cruise destinations on both sides of the Atlantic Ocean. With an MSC Transatlantic cruise, you can experience amazing city breaks and the best the cruise line’s ships have to offer in between destinations. Sail on a cruise from the UK or depart on a North America cruise.

MSC Cruises MSC Cruises from Southampton MSC Mini Cruises

MSC Last Minute Cruises MSC Cruises 2025 MSC Cruises 2026

Looking for the best cruise deals on our MSC Transatlantic cruises? Book your cruise deal online with Cruise118.com and enjoy the ultimate cruise holiday aboard an MSC Transatlantic cruise.


Filters
Northern Europe 5 Nights From Southampton
Southampton | Zeebrugge | Rotterdam | Cherbourg | Southampton
19 Oct 2026
5 Nights
Northern Europe

Departs from the UK
Book now with Cruise118.com and save up to an extra 6%!
Interest free Monthly Payments from JUST £18pp
Cruise Only From
Was £599pp
Now: £469
pp
REF: MSCVI20261019SOUSOU
Northern Europe 7 Nights From Southampton
Southampton | La Rochelle | Bilbao | La Coruña | Le Havre | Southampton
24 Oct 2026
7 Nights
Northern Europe

Departs from the UK
Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £31pp
Cruise Only From
Was £799pp
Now: £751
pp
REF: MSCVI20261024SOUSOU
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
24 Oct 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £63pp
Cruise Only From
Was £1509pp
Now: £1418
pp
REF: MSCAM20261024MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
24 Oct 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £31pp
Cruise Only From
Was £789pp
Now: £742
pp
REF: MSCAM20261024MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
31 Oct 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £61pp
Cruise Only From
Was £1469pp
Now: £1381
pp
REF: MSCAM20261031MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
31 Oct 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £28pp
Cruise Only From
Was £719pp
Now: £676
pp
REF: MSCAM20261031MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
07 Nov 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £59pp
Cruise Only From
Was £1419pp
Now: £1334
pp
REF: MSCAM20261107MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
07 Nov 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £29pp
Cruise Only From
Was £749pp
Now: £704
pp
REF: MSCAM20261107MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
14 Nov 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £60pp
Cruise Only From
Was £1509pp
Now: £1418
pp
REF: MSCAM20261114MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
14 Nov 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £25pp
Cruise Only From
Was £669pp
Now: £629
pp
REF: MSCAM20261114MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
21 Nov 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £60pp
Cruise Only From
Was £1509pp
Now: £1418
pp
REF: MSCAM20261121MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
21 Nov 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £32pp
Cruise Only From
Was £839pp
Now: £789
pp
REF: MSCAM20261121MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
28 Nov 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £55pp
Cruise Only From
Was £1389pp
Now: £1306
pp
REF: MSCAM20261128MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
28 Nov 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £25pp
Cruise Only From
Was £669pp
Now: £629
pp
REF: MSCAM20261128MIAMIA
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
05 Dec 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £27pp
Cruise Only From
Was £719pp
Now: £676
pp
REF: MSCAM20261205MIAMIA
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
05 Dec 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £55pp
Cruise Only From
Was £1389pp
Now: £1306
pp
REF: MSCAM20261205MIAMI1
Caribbean 14 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
12 Dec 2026
14 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £64pp
Cruise Only From
Was £1669pp
Now: £1569
pp
REF: MSCAM20261212MIAMI1
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Puerto Plata | San Juan (Puerto Rico) | Ocean Cay, MSC Marine Reserve | Miami, Florida
12 Dec 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £23pp
Cruise Only From
Was £669pp
Now: £629
pp
REF: MSCAM20261212MIAMIA
Caribbean 7 Nights From Miami, Florida
Miami, Florida | Roatán Island | Costa Maya | Cozumel | Ocean Cay, MSC Marine Reserve | Miami, Florida
19 Dec 2026
7 Nights
Caribbean

Book now with Cruise118.com and save up to an extra 6%!
ONLINE BOOKING SALE! Save up to an extra £50 per stateroom! Code Balcony: WEEKEND30 | Suite: WEEKEND50
Interest free Monthly Payments from JUST £37pp
Cruise Only From
Was £999pp
Now: £939
pp
REF: MSCAM20261219MIAMIA

Why Choose An MSC Transatlantic Cruise?

Choose to travel in either direction across the Atlantic Ocean on one of MSC Cruises’ fantastic Transatlantic cruises. These exceptional MSC Transatlantic cruise voyages will take travellers to exotic and fascinating locations on North and South America cruises, from the bustling US cities of New York and Miami on a fly-cruise to the vibrant South American nations of Brazil and Argentina. European ports include Amsterdam and several locations in the United Kingdom and Mediterranean cruise regions.

Choose A Transatlantic Cruise From The UK

With a great range of MSC Transatlantic cruises sailing from ports on both sides of the Atlantic, you may be tempted by a fly cruise holiday, but you can also choose a cruise from Southampton, depart on a cruise from the UK and skip the hassle of flying as you set sail right from where you park your car.

Book Your MSC Transatlantic Cruise

There’s never been a better time to head on an MSC Transatlantic cruise. With cruises all year round, you can top up your tan on a summer cruise in Miami or stop in New York for Christmas on a winter cruise. Whenever you decide to head on your Transatlantic cruise, be sure to book through Cruise118.com and benefit from amazing cruise deals.

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